Biomolecular condensates appear throughout cell physiology and pathology, but the
specific role of condensation or its dynamics is often difficult to determine. Optogenetics …

Optogenetic, known as the method of 21 centuries, combines optic and genetic engineering
to precisely control photosensitive proteins for manipulation of a broad range of cellular …

Protein clustering is a powerful form of optogenetic control, yet remarkably few proteins are
known to oligomerize with light. Recently, the photoreceptor BcLOV4 was found to form …

The emerging field of synthetic morphogenesis implements synthetic biology tools to
investigate the minimal cellular processes sufficient for orchestrating key developmental …

Stem cell-based embryo models, which recapitulate symmetry breaking, pattern formation
and tissue morphogenesis during early development, provide promising experimental tools …

The capability of human pluripotent stem cells (hPSCs) to self-renew and differentiate into
any cell type has greatly contributed to the advancement of biomedicine. Reporter lines …

The spatial distribution of the signaling molecules that mediate cell-cell communication and
pattern formation is an important consideration for natural and engineered multicellular …

Protein clustering is a powerful form of optogenetic control, yet there is currently only one
protein—Cry2—whose light-induced clustering has been harnessed for these purposes …

Pluripotent stem cells (PSCs), characterized by self-renewal and capacity of differentiating
into three germ layers, are the programmable building blocks of life. PSC-derived cells and …

Notochord progenitors (NotoPs) represent a scarce yet crucial embryonic cell population,
playing important roles in embryo patterning and eventually giving rise to the cells that form …