Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every
tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular …

The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …

The expressive number of deaths and confirmed cases of SARS-CoV-2 call for an urgent
demand of effective and available drugs for COVID-19 treatment. CD147, a receptor on host …

Although pulmonary fibrosis can occur in the absence of a clear‐cut inciting agent, and
without a clinically clear initial acute inflammatory phase, it is more commonly associated …

The newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has caused a pandemic of respiratory illness. Current evidence suggests …

Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …