Subunit composition, distribution and function of GABA-A receptor subtypes
W Sieghart, G Sperk - Current topics in medicinal chemistry, 2002 - ingentaconnect.com
GABA-A receptors are the major inhibitory neurotransmitter receptors in the brain and are
the site of action of many clinically important drugs. These receptors are composed of five …
the site of action of many clinically important drugs. These receptors are composed of five …
Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system
Communication between nerve cells in the central nervous system (CNS) occurs at
synapses, which are specialized sites between the presynaptic nerve terminal and the …
synapses, which are specialized sites between the presynaptic nerve terminal and the …
[BOOK][B] Ion channels and disease
FM Ashcroft - 1999 - books.google.com
Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …
across cell membranes. They play essential roles in the physiology of all cells. In recent …
Primary Structure And Functional Expression of the 5HT3 Receptor, A Serotonin-gated Ion Channel
AV Maricq, AS Peterson, AJ Brake, RM Myers, D Julius - Science, 1991 - science.org
The neurotransmitter serotonin (5HT) activates a variety of second messenger signaling
systems and through them indirectly regulates the function of ion channels. Serotonin also …
systems and through them indirectly regulates the function of ion channels. Serotonin also …
Cloning by functional expression of a member of the glutamate receptor family
M Hollmann, A O'Shea-Greenfield, SW Rogers… - Nature, 1989 - nature.com
We have isolated a complementary DNA clone by screening a rat brain cDNA library for
expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single …
expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single …
The diversity of GABAA receptors: Pharmacological and electrophysiological properties of GABAA channel subtypes
W Hevers, H Lüddens - Molecular neurobiology, 1998 - Springer
The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …
GABA receptor mechanisms in the central nervous system
L Sivilotti, A Nistri - Progress in neurobiology, 1991 - Elsevier
C1 equilibrium potential 1PSP reversal potential Dose producing a half-maximal response
Excitatory postsynaptic potential y-Aminobutyric acid GABA transaminase Glutamic acid …
Excitatory postsynaptic potential y-Aminobutyric acid GABA transaminase Glutamic acid …
A point mutation in a Drosophila GABA receptor confers insecticide resistance
RH Ffrench-Constant, TA Rocheleau, JC Steichen… - Nature, 1993 - nature.com
VERTEBRATES and invertebrates both have GABA (γ-aminobutyric acid) as a major
inhibitory neurotransmitter1, 2. GABAA receptors in vertebrates assemble as …
inhibitory neurotransmitter1, 2. GABAA receptors in vertebrates assemble as …
The role of GABAA receptors in mediating the effects of alcohol in the central nervous system
M Davies - Journal of Psychiatry and Neuroscience, 2003 - jpn.ca
Ethanol is a chemically simple compound that produces many well-known effects in
humans. The prevailing idea for many years was that ethanol and other alcohols exerted …
humans. The prevailing idea for many years was that ethanol and other alcohols exerted …
The effect of subunit composition of rat brain GABAA receptors on channel function
E Sigel, R Baur, G Trube, H Möhler, P Malherbe - Neuron, 1990 - cell.com
Different combinations of cloned rat brain subunit isoforms of the GABAA receptor channel
were expressed in Xenopus oocytes. The voltage-clamp technique was then used to …
were expressed in Xenopus oocytes. The voltage-clamp technique was then used to …