Guidelines for acquisition, interpretation, and reporting of whole-body MRI in myeloma: myeloma response assessment and diagnosis system (MY-RADS)

C Messiou, J Hillengass, S Delorme, FE Lecouvet… - Radiology, 2019 - pubs.rsna.org
Acknowledging the increasingly important role of whole-body MRI for directing patient care
in myeloma, a multidisciplinary, international, and expert panel of radiologists, medical …

Toward personalized treatment in multiple myeloma based on molecular characteristics

C Pawlyn, FE Davies - Blood, The Journal of the American …, 2019 - ashpublications.org
To date, the choice of therapy for an individual multiple myeloma patient has been based on
clinical factors such as age and comorbidities. The widespread evolution, validation, and …

Standardization of 18F-FDG–PET/CT According to Deauville Criteria for Metabolic Complete Response Definition in Newly Diagnosed Multiple Myeloma

E Zamagni, C Nanni, L Dozza, T Carlier… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed
tomography (CT) is currently the standard technique to define minimal residual disease …

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level

L John, AM Poos, A Brobeil, C Schinke, S Huhn… - Nature …, 2023 - nature.com
In multiple myeloma spatial differences in the subclonal architecture, molecular signatures
and composition of the microenvironment remain poorly characterized. To address this …

The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states

L Rasche, C Schinke, F Maura, MA Bauer… - Nature …, 2022 - nature.com
Abstract Deciphering Multiple Myeloma evolution in the whole bone marrow is key to inform
curative strategies. Here, we perform spatial-longitudinal whole-exome sequencing …

Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma

L Rasche, D Alapat, M Kumar, G Gershner, J McDonald… - Leukemia, 2019 - nature.com
The iliac crest is the sampling site for minimal residual disease (MRD) monitoring in multiple
myeloma (MM). However, the disease distribution is often heterogeneous, and imaging can …

Bispecific antibodies for multiple myeloma: a review of targets, drugs, clinical trials, and future directions

C Caraccio, S Krishna, DJ Phillips… - Frontiers in …, 2020 - frontiersin.org
Multiple myeloma (MM) is a plasma cell malignancy and the second most common
hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual incidence …

Molecular and immunological mechanisms of clonal evolution in multiple myeloma

S Forster, R Radpour, AF Ochsenbein - Frontiers in immunology, 2023 - frontiersin.org
Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of
clonal plasma cells in the bone marrow (BM). It is known that early genetic mutations in post …

High‐risk multiple myeloma: redefining genetic, clinical, and functional high‐risk disease in the era of molecular medicine and immunotherapy

MJ Rees, S Kumar - American journal of hematology, 2024 - Wiley Online Library
Multiple myeloma (MM) exhibits significant heterogeneity in its presentation, genetics, and
treatment response. Despite therapeutic advances, some patients continue to relapse early …

Minimal residual disease in myeloma: application for clinical care and new drug registration

KC Anderson, D Auclair, SJ Adam… - Clinical cancer …, 2021 - aacrjournals.org
The development of novel agents has transformed the treatment paradigm for multiple
myeloma, with minimal residual disease (MRD) negativity now achievable across the entire …