Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …

ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …

PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …

Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …

In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …

The functionality of DNA, RNA and proteins is altered dynamically in response to
physiological and pathological cues, partly achieved by their modification. While the …

Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are
fundamental for creating the tools needed to explore this elusive post-translational …

Summary Poly (ADP-ribose)(PAR) is an RNA-like polymer that regulates an increasing
number of biological processes. Dysregulation of PAR is implicated in neurodegenerative …

Background Approximately two third of patients with a rare genetic disease remain
undiagnosed after exome sequencing (ES). As part of our post-test counseling procedures …

Abstract Poly (ADP-ribosyl) ation (PAR) is a versatile and complex posttranslational
modification composed of repeating units of ADP-ribose arranged into linear or branched …