Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology

AB Theberge, F Courtois, Y Schaerli… - Angewandte Chemie …, 2010 - Wiley Online Library
Microdroplets in microfluidics offer a great number of opportunities in chemical and
biological research. They provide a compartment in which species or reactions can be …

Droplet-based microfluidics: enabling impact on drug discovery

OJ Dressler, RM Maceiczyk… - Journal of …, 2014 - journals.sagepub.com
Over the past two decades, the application of microengineered systems in the chemical and
biological sciences has transformed the way in which high-throughput experimentation is …

Suzuki–Miyaura cross-coupling optimization enabled by automated feedback

BJ Reizman, YM Wang, SL Buchwald… - Reaction chemistry & …, 2016 - pubs.rsc.org
An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki–
Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to …

[หนังสือ][B] Micro reaction technology in organic synthesis

C Wiles, P Watts - 2016 - books.google.com
A valuable resource for the modern synthetic chemist, this broadly applicable book
addresses the multidisciplinary field of micro reaction technology-from novel research …

[HTML][HTML] Stabilisers for water-in-fluorinated-oil dispersions: Key properties for microfluidic applications

P Gruner, B Riechers, LAC Orellana… - Current Opinion in …, 2015 - Elsevier
Droplet-based microfluidics appears as a key emerging technology for the miniaturization
and automation of biochemical assays. In terms of technology, it stands on two basic pillars …

Microfluidic platform for combinatorial synthesis in picolitre droplets

AB Theberge, E Mayot, A El Harrak, F Kleinschmidt… - Lab on a Chip, 2012 - pubs.rsc.org
This paper presents a droplet-based microfluidic platform for miniaturized combinatorial
synthesis. As a proof of concept, a library of small molecules for early stage drug screening …

Recent Advancements in Continuous‐Flow Suzuki‐Miyaura Coupling Utilizing Immobilized Molecular Palladium Complexes

Z Zhang, YMA Yamada - Chemistry–A European Journal, 2024 - Wiley Online Library
Abstract Immobilized Pd‐catalyzed Suzuki‐Miyaura coupling under continuous‐flow
conditions using a packed‐bed reactor, representing an efficient, automated, practical, and …

Flow chemistry in contemporary chemical sciences: A real variety of its applications

M Trojanowicz - Molecules, 2020 - mdpi.com
Background: Open Access Editor's Choice Review Flow Chemistry in Contemporary
Chemical Sciences: A Real Variety of Its Applications by Marek Trojanowicz 1, 2 1 …

Palladium‐Catalyzed Combinatorial Synthesis of Biphenyls on Droplet Microarrays at Nanoliter Scale

J Höpfner, M Brehm, PA Levkin - Small, 2024 - Wiley Online Library
The rising costs of pharmaceutical research are currently limiting the productivity of drug
discovery and development, but can potentially be diminished via miniaturization of the …

Conversion efficiencies of a few living microbial cells detected at a high throughput by droplet-based ESI-MS

M Schirmer, K Wink, S Ohla, D Belder… - Analytical …, 2020 - ACS Publications
The label-free and sensitive detection of synthesis products from single microbial cells
remains the bottleneck for determining the specific turnover numbers of individual whole-cell …