The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …
Adult neurogenesis, glia, and the extracellular matrix
EC Cope, E Gould - Cell Stem Cell, 2019 - cell.com
In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …
An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity
D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …
Impact of perineuronal nets on electrophysiology of parvalbumin interneurons, principal neurons, and brain oscillations: a review
Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …
specific neurons in the brain and spinal cord, appear during critical periods of development …
Perineuronal nets: plasticity, protection, and therapeutic potential
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …
Exercise-induced plasticity in signaling pathways involved in motor recovery after spinal cord injury
Spinal cord injury (SCI) leads to numerous chronic and debilitating functional deficits that
greatly affect quality of life. While many pharmacological interventions have been explored …
greatly affect quality of life. While many pharmacological interventions have been explored …
The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases
Y Dong, K Zhao, X Qin, G Du, L Gao - Ageing Research Reviews, 2023 - Elsevier
The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …
Neuron‐glia interactions in neural plasticity: contributions of neural extracellular matrix and perineuronal nets
Synapses are specialized structures that mediate rapid and efficient signal transmission
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …
Perineuronal nets: subtle structures with large implications
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …
the soma and proximal dendrites of certain neurons in the central nervous system …
Cerebellar plasticity and associative memories are controlled by perineuronal nets
D Carulli, R Broersen, F de Winter… - Proceedings of the …, 2020 - National Acad Sciences
Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround
the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are …
the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are …