Allogeneic transplantation of hematopoietic cells is an effective treatment of leukemia, even
in advanced stages. Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) …

Acute graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow
transplantation (BMT), limits the application of this curative but toxic therapy. Studies of …

Idiopathic pneumonia syndrome (IPS) refers to diffuse, non-infectious pneumonia that
occurs after allogeneic bone marrow transplantation (BMT). We have developed a model of …

The influence of bone marrow transplantation (BMT) conditioning regimens on the incidence
and severity of graft-versus-host disease (GVHD) has been suggested in clinical BMT. Using …

Background Interleukin 6 mediates graft-versus-host disease (GVHD) in experimental
allogeneic stem-cell transplantation (allogeneic SCT) and represents an attractive …

Complications of allogeneic hematopoietic stem cell transplantation (HSCT) remain barriers
to its wider application for a variety of diseases. Graft-versus-host disease (GVHD) is the …

The inflammatory cytokine tumor necrosis factor (TNF), as well as most other ligand
members of the TNF superfamily, exist both as classical soluble cytokines, but also in the …

During the past decade, progress in basic immunology has been impressive. In parallel,
whereas our understanding of the pathophysiology of acute graft-versus-host disease …

Donor T cell responses to host alloantigen are known predictors for graft-versus-host
disease (GVHD); however, the effect of donor responsiveness to an inflammatory stimulus …

Certain cytokines, the prototype being the highly pleiotropic TNF, have many homeostatic
physiological roles, are involved in innate immunity, and cause inflammation when in …