Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Ten years after the first overview of a complete plant Hsf family was presented for
Arabidopsis thaliana by Nover et al.[1], we compiled data for 252 Hsfs from nine plant …

The heat shock response (HSR) is critical for survival of all organisms. However, its scope,
extent, and the molecular mechanism of regulation are poorly understood. Here we show …

Acute stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival.
Cellular adaptation mechanisms include modification of certain aspects of cell physiology …

Proteotoxic stress, that is, stress caused by protein misfolding and aggregation, triggers the
rapid and global reprogramming of transcription at genes and enhancers. Genome-wide …

Pioneer transcription factors recognise and bind their target sequences in inaccessible
chromatin to establish new transcriptional networks throughout development and cellular …

Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) has
become the dominant technique for map** transcription factor (TF) binding regions …

Members of transcription factor families typically have similar DNA binding specificities yet
execute unique functions in vivo. Transcription factors often bind DNA as multiprotein …

ABSTRACT Heat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription
factor that coordinates stress-induced transcription and directs versatile physiological …

Most human transcription factors bind a small subset of potential genomic sites and often
use different subsets in different cell types. To identify mechanisms that govern cell-type …