Emerging new therapeutic antibody derivatives for cancer treatment

S **, Y Sun, X Liang, X Gu, J Ning, Y Xu… - Signal transduction and …, 2022 - nature.com
Monoclonal antibodies constitute a promising class of targeted anticancer agents that
enhance natural immune system functions to suppress cancer cell activity and eliminate …

Site-selective modification strategies in antibody–drug conjugates

SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

Antibody-displaying extracellular vesicles for targeted cancer therapy

OPB Wiklander, DR Mamand, DK Mohammad… - Nature biomedical …, 2024 - nature.com
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological
signals across tissues. Here, by leveraging these functionalities, we show that EVs …

Ligand-targeted drug delivery

M Srinivasarao, PS Low - Chemical reviews, 2017 - ACS Publications
Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

[HTML][HTML] Orientation and characterization of immobilized antibodies for improved immunoassays

NG Welch, JA Scoble, BW Muir, PJ Pigram - Biointerphases, 2017 - pubs.aip.org
Orientation of surface immobilized capture proteins, such as antibodies, plays a critical role
in the performance of immunoassays. The sensitivity of immunodiagnostic procedures is …

In vitro reconstitution of a highly processive recombinant human dynein complex

MA Schlager, HT Hoang, L Urnavicius… - The EMBO …, 2014 - embopress.org
Cytoplasmic dynein is an approximately 1.4 MDa multi‐protein complex that transports many
cellular cargoes towards the minus ends of microtubules. Several in vitro studies of …

[HTML][HTML] Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications

J Löfblom, J Feldwisch, V Tolmachev, J Carlsson… - FEBS letters, 2010 - Elsevier
Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …

Artificial Multienzyme Scaffolds: Pursuing in Vitro Substrate Channeling with an Overview of Current Progress

GA Ellis, WP Klein, G Lasarte-Aragonés, M Thakur… - ACS …, 2019 - ACS Publications
Artificial multienzyme scaffolds are being developed for in vitro cascaded biocatalytic activity
and, in particular, accessing substrate channeling. This review covers progress in this field …

Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain

K Nord, E Gunneriusson, J Ringdahl, S Ståhl… - Nature …, 1997 - nature.com
Small protein domains, capable of specific binding to different target proteins have been
selected using combinatorial approaches. These binding proteins, called affibodies, were …

Fc-binding ligands of immunoglobulin G: an overview of high affinity proteins and peptides

W Choe, TA Durgannavar, SJ Chung - Materials, 2016 - mdpi.com
The rapidly increasing application of antibodies has inspired the development of several
novel methods to isolate and target antibodies using smart biomaterials that mimic the …