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Emerging new therapeutic antibody derivatives for cancer treatment
S **, Y Sun, X Liang, X Gu, J Ning, Y Xu… - Signal transduction and …, 2022 - nature.com
Monoclonal antibodies constitute a promising class of targeted anticancer agents that
enhance natural immune system functions to suppress cancer cell activity and eliminate …
enhance natural immune system functions to suppress cancer cell activity and eliminate …
Site-selective modification strategies in antibody–drug conjugates
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
Antibody-displaying extracellular vesicles for targeted cancer therapy
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological
signals across tissues. Here, by leveraging these functionalities, we show that EVs …
signals across tissues. Here, by leveraging these functionalities, we show that EVs …
Ligand-targeted drug delivery
Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
[HTML][HTML] Orientation and characterization of immobilized antibodies for improved immunoassays
Orientation of surface immobilized capture proteins, such as antibodies, plays a critical role
in the performance of immunoassays. The sensitivity of immunodiagnostic procedures is …
in the performance of immunoassays. The sensitivity of immunodiagnostic procedures is …
In vitro reconstitution of a highly processive recombinant human dynein complex
Cytoplasmic dynein is an approximately 1.4 MDa multi‐protein complex that transports many
cellular cargoes towards the minus ends of microtubules. Several in vitro studies of …
cellular cargoes towards the minus ends of microtubules. Several in vitro studies of …
[HTML][HTML] Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications
Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 …
Artificial Multienzyme Scaffolds: Pursuing in Vitro Substrate Channeling with an Overview of Current Progress
Artificial multienzyme scaffolds are being developed for in vitro cascaded biocatalytic activity
and, in particular, accessing substrate channeling. This review covers progress in this field …
and, in particular, accessing substrate channeling. This review covers progress in this field …
Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain
K Nord, E Gunneriusson, J Ringdahl, S Ståhl… - Nature …, 1997 - nature.com
Small protein domains, capable of specific binding to different target proteins have been
selected using combinatorial approaches. These binding proteins, called affibodies, were …
selected using combinatorial approaches. These binding proteins, called affibodies, were …
Fc-binding ligands of immunoglobulin G: an overview of high affinity proteins and peptides
The rapidly increasing application of antibodies has inspired the development of several
novel methods to isolate and target antibodies using smart biomaterials that mimic the …
novel methods to isolate and target antibodies using smart biomaterials that mimic the …