It is generally accepted that recent advances in anticancer agents have contributed
significantly to the improvement of both the disease-free survival and quality of life in cancer …

▪ Abstract The taxane class of antimicrotubule anticancer agents is perhaps the most
important addition to the chemotherapeutic armamentarium against cancer over the past …

Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility.
Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs …

Acquired resistance to paclitaxel can be mediated by P-glycoprotein or by alterations
involving tubulin. We report two paclitaxel-resistant sublines derived from 1A9 human …

Tubulin, the subunit protein of microtubules, is an α/β heterodimer. In many organisms, both
α and β exist in numerous isotypic forms encoded by different genes. In addition, both α and …

Over the past decade, significant progress has been made in our understanding of the
biology of microtubule (MT) assembly into the mitotic spindle during mitosis and the …

It has been approximately ten years since the Food and Drug Administration (FDA)
approved paclitaxel for the treatment of platinum resistant epithelial ovarian carcinoma …

We have obtained a 3D reconstruction of intact microtubules, using cryoelectron microscopy
and image processing, at a resolution of about 8 Å, sufficient to resolve much of the …

This multicenter prospective phase II study examines the activity and tolerability of
brentuximab vedotin as second-line therapy in patients with Hodgkin lymphoma that was …

Multidrug transporters constitute major mechanisms of MDR in human cancers. The ABCB1
(MDR1) gene encodes a well-characterized transmembrane transporter, termed P …