NORMAN guidance on suspect and non-target screening in environmental monitoring

J Hollender, EL Schymanski, L Ahrens… - Environmental Sciences …, 2023 - Springer
Increasing production and use of chemicals and awareness of their impact on ecosystems
and humans has led to large interest for broadening the knowledge on the chemical status …

Current state-of-the-art of separation methods used in LC-MS based metabolomics and lipidomics

EM Harrieder, F Kretschmer, S Böcker… - … of Chromatography B, 2022 - Elsevier
Metabolomics deals with the large-scale analysis of metabolites, belonging to numerous
compound classes and showing an extremely high chemical diversity and complexity …

Retention time prediction for chromatographic enantioseparation by quantile geometry-enhanced graph neural network

H Xu, J Lin, D Zhang, F Mo - Nature Communications, 2023 - nature.com
The enantioseparation of chiral molecules is a crucial and challenging task in the field of
experimental chemistry, often requiring extensive trial and error with different experimental …

RepoRT: a comprehensive repository for small molecule retention times

F Kretschmer, EM Harrieder, MA Hoffmann, S Böcker… - Nature …, 2024 - nature.com
Liquid chromatography (LC) is fre-quently used to separate metabolites and other small
molecules. Retention time is the time required for a particular molecule to pass through the …

Joint structural annotation of small molecules using liquid chromatography retention order and tandem mass spectrometry data

E Bach, EL Schymanski, J Rousu - Nature Machine Intelligence, 2022 - nature.com
Structural annotation of small molecules in biological samples remains a key bottleneck in
untargeted metabolomics, despite rapid progress in predictive methods and tools during the …

Retention time dataset for heterogeneous molecules in reversed–phase liquid chromatography

Y Zhang, F Liu, XQ Li, Y Gao, KC Li, QH Zhang - Scientific Data, 2024 - nature.com
Quantitative structure–property relationships have been extensively studied in the field of
predicting retention times in liquid chromatography (LC). However, making transferable …

Retention Time Prediction through Learning from a Small Training Data Set with a Pretrained Graph Neural Network

Y Kwon, H Kwon, J Han, M Kang, JY Kim… - Analytical …, 2023 - ACS Publications
Graph neural networks (GNNs) have shown remarkable performance in predicting the
retention time (RT) for small molecules. However, the training data set for a particular target …

[HTML][HTML] Identification of nutritional biomarkers through highly sensitive and chemoselective metabolomics

W Lin, K Mellinghaus, A Rodriguez-Mateos, D Globisch - Food Chemistry, 2023 - Elsevier
The importance of a healthy diet for humans is known for decades. The elucidation of key
molecules responsible for the beneficial and adverse dietary effects is slowly develo** as …

Insights into predicting small molecule retention times in liquid chromatography using deep learning

Y Liu, AC Yoshizawa, Y Ling, S Okuda - Journal of Cheminformatics, 2024 - Springer
In untargeted metabolomics, structures of small molecules are annotated using liquid
chromatography-mass spectrometry by leveraging information from the molecular retention …

Explicit relation between thin film chromatography and column chromatography conditions from statistics and machine learning

H Xu, W Wu, Y Chen, D Zhang, F Mo - Nature Communications, 2025 - nature.com
In chemistry, empirical paradigms prevail, especially within the realm of chromatography,
where the selection of separation conditions frequently relies on the chemist's experience …