Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

M Valles-Colomer, C Menni, SE Berry, AM Valdes… - Nature Medicine, 2023 - nature.com
Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …

The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Metabolomics and molecular approaches reveal drought stress tolerance in plants

M Kumar, M Kumar Patel, N Kumar, AB Bajpai… - International Journal of …, 2021 - mdpi.com
Metabolic regulation is the key mechanism implicated in plants maintaining cell osmotic
potential under drought stress. Understanding drought stress tolerance in plants will have a …

Nuclear magnetic resonance (NMR) spectroscopy in food science: A comprehensive review

E Hatzakis - Comprehensive reviews in food science and food …, 2019 - Wiley Online Library
Nuclear magnetic resonance (NMR) spectroscopy is a robust method, which can rapidly
analyze mixtures at the molecular level without requiring separation and/or purification …

Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

[HTML][HTML] Regulation of ferroptotic cancer cell death by GPX4

WS Yang, R SriRamaratnam, ME Welsch, K Shimada… - Cell, 2014 - cell.com
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown.
We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules …

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

Analytical methods in untargeted metabolomics: state of the art in 2015

A Alonso, S Marsal, A Julià - Frontiers in bioengineering and …, 2015 - frontiersin.org
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

A Whitehead, FN Krause, A Moran… - Nature …, 2021 - nature.com
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues
are functionally associated with skeletal muscle, adipose tissue metabolism and systemic …