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Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Interstitial cells: regulators of smooth muscle function
Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells.
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …
Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
D Dicker, G Nguyen, D Abate, KH Abate, SM Abay… - The lancet, 2018 - thelancet.com
Background Assessments of age-specific mortality and life expectancy have been done by
the UN Population Division, Department of Economics and Social Affairs (UNPOP), the …
the UN Population Division, Department of Economics and Social Affairs (UNPOP), the …
Structure and function of TMEM16 proteins (anoctamins)
TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …
Regulation of gastrointestinal motility—insights from smooth muscle biology
Gastrointestinal motility results from coordinated contractions of the tunica muscularis, the
muscular layers of the alimentary canal. Throughout most of the gastrointestinal tract …
muscular layers of the alimentary canal. Throughout most of the gastrointestinal tract …
Gastrointestinal stromal tumors
M Miettinen, J Lasota - Gastroenterology Clinics of North …, 2013 - pmc.ncbi.nlm.nih.gov
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the
gastrointestinal tract. Soon after GIST was recognized as a tumor driven by a KIT or …
gastrointestinal tract. Soon after GIST was recognized as a tumor driven by a KIT or …
[HTML][HTML] The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …
while some family members function as Ca 2+-activated anion channels, the majority of …
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression
Frequent gene amplification of the receptor-activated calcium-dependent chloride channel
TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its …
TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its …
[HTML][HTML] Understanding the biology of human interstitial cells of Cajal in gastrointestinal motility
D Foong, J Zhou, A Zarrouk, V Ho… - International Journal of …, 2020 - mdpi.com
Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as
gastroparesis. These disorders typically include debilitating symptoms, such as chronic …
gastroparesis. These disorders typically include debilitating symptoms, such as chronic …
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells
W Namkung, PW Phuan, AS Verkman - Journal of Biological Chemistry, 2011 - jbc.org
TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). We
developed pharmacological tools to investigate the contribution of TMEM16A to CaCC …
developed pharmacological tools to investigate the contribution of TMEM16A to CaCC …