Atherosclerosis is a chronic inflammatory disease associated with cardiovascular
dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

The seventeenth edition of Harrison s has a full-color format that draws from and extends the
excellent appearance of the sixteenth edition to make the content more accessible and …

The view of atherosclerosis as an inflammatory disease has emerged from observations of
immune activation and inflammatory signalling in human atherosclerotic lesions, from the …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

This review of leukotrienes, which are lipid mediators with a broad array of clinical effects,
and leukotriene receptors considers the biochemical and physiological aspects of these …

Atherosclerosis has long been known as an inflammatory disease. However, whether
targeting inflammation improves outcomes was unproven until the recent results of CANTOS …

Atherosclerosis is characterized by the thickening of the arterial wall and is the primary
cause of coronary artery disease and cerebrovascular disease, two of the most common …

Before we discuss lipids and their role in homeostasis and host defense, we will recount the
essence of the inflammatory response. Inflammation is a reaction of the microcirculation; it's …