Dose painting is the prescription of a nonuniform radiation dose distribution to the target
volume based on functional or molecular images shown to indicate the local risk of relapse …

Lung cancer radiation therapy (RT) is associated with complex geometrical uncertainties,
such as respiratory motion, differential baseline shifts between primary tumor and involved …

Importance Our previous studies demonstrated that tumors significantly decrease in size and
metabolic activity after delivery of 45 Gy of fractionated radiatiotherapy (RT), and that …

Background Although altered protocols that challenge conventional radiation fractionation
have been tested in prospective clinical trials, we still have limited understanding of how to …

PURPOSE NRG-RTOG0617 demonstrated a detrimental effect of uniform high-dose
radiation in stage III non–small cell lung cancer. NRG-RTOG1106/ECOG-ACRIN6697 …

Purpose We previously showed that individualized radiation dose escalation based on
normal tissue constraints would allow safe administration of high radiation doses with low …

Positron emission tomography can be used in radiation oncology for the delineation of target
volumes in the treatment planning stage. Numerous publications deal with this topic and the …

Background and purpose The PET-boost randomized phase II trial (NCT01024829)
investigated dose-escalation to the entire primary tumour or redistributed to regions of high …

Importance Intrathoracic progression remains the predominant pattern of failure in patients
treated with concurrent chemoradiation followed by a consolidation immune checkpoint …

Purpose Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur
in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT …