GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Treatment of certain central nervous system disorders, including different types of cerebral
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …

Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are morpho-functional
units, formed at the loci of close apposition of the ER-forming endomembrane and outer …

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-
range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

Since constant perfusion of blood throughout the brain is critical for neuronal health, the
regulation of cerebral blood flow is complex and highly controlled. This regulation is …

Background: Neurovascular coupling (NVC) is the mechanism whereby an increase in
neuronal activity (NA) leads to local elevation in cerebral blood flow (CBF) to match the …