Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes
Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …
Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp …
M Borowiak, J Fischer, JA Hammerl… - Journal of …, 2017 - academic.oup.com
Objectives Plasmid-mediated mobilized colistin resistance is currently known to be caused
by phosphoethanolamine transferases termed MCR-1, MCR-2, MCR-3 and MCR-4 …
by phosphoethanolamine transferases termed MCR-1, MCR-2, MCR-3 and MCR-4 …
RESTORE-IMI 1: a multicenter, randomized, double-blind trial comparing efficacy and safety of imipenem/relebactam vs colistin plus imipenem in patients with …
J Motsch, C Murta de Oliveira, V Stus… - Clinical Infectious …, 2020 - academic.oup.com
Background The β-lactamase inhibitor relebactam can restore imipenem activity against
imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam …
imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam …
Colistin, mechanisms and prevalence of resistance
Background: Infections caused by multi-drug-resistant Gram-negative bacteria, particularly
Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, that …
Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, that …
Polymyxins and bacterial membranes: a review of antibacterial activity and mechanisms of resistance
C Ayoub Moubareck - Membranes, 2020 - mdpi.com
Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …
Colistin in pig production: chemistry, mechanism of antibacterial action, microbial resistance emergence, and one health perspectives
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in
both human and veterinary medicine. For several years now, colistin has been considered …
both human and veterinary medicine. For several years now, colistin has been considered …
Pharmacology of polymyxins: new insights into an 'old'class of antibiotics
Increasing antibiotic resistance in Gram-negative bacteria, particularly in Pseudomonas
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …
The concept of an ideal antibiotic: implications for drug design
M Gajdács - Molecules, 2019 - mdpi.com
The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …
Treatment Options for Carbapenem-Resistant Enterobacteriaceae Infections
This article provides a comprehensive review of currently available treatment options for
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …