Chemical approaches to optimize the properties of organic fluorophores for imaging and sensing

G Jiang, H Liu, H Liu, G Ke, TB Ren… - Angewandte …, 2024‏ - Wiley Online Library
Organic fluorophores are indispensable tools in cells, tissue and in vivo imaging, and have
enabled much progress in the wide range of biological and biomedical fields. However …

Near-infrared dyes for two-photon absorption in the short-wavelength infrared: strategies towards optical power limiting

S Pascal, S David, C Andraud, O Maury - Chemical Society Reviews, 2021‏ - pubs.rsc.org
This work provides an overview of the recent advances in the field of two-photon absorbing
chromophores active in the short-wavelength infrared (SWIR) spectral range. Herein the …

Stable, bright, and long-fluorescence-lifetime dyes for deep-near-infrared bioimaging

J Li, Y Dong, R Wei, G Jiang, C Yao, M Lv… - Journal of the …, 2022‏ - ACS Publications
Near-infrared (NIR) fluorophores absorbing maximally in the region beyond 800 nm, ie,
deep-NIR spectral region, are actively sought for biomedical applications. Ideal dyes are …

Rigid and photostable shortwave infrared dye absorbing/emitting beyond 1200 nm for high-contrast multiplexed imaging

R Wei, Y Dong, X Wang, J Li, Z Lei, Z Hu… - Journal of the …, 2023‏ - ACS Publications
The shortwave infrared (SWIR) spectral region beyond 1200 nm offers optimal tissue
penetration depth and has broad potential in diagnosis, therapy, and surgery. Here, we …

Small molecular cyanine dyes for phototheranostics

J Zhang, W Wang, J Shao, J Chen, X Dong - Coordination Chemistry …, 2024‏ - Elsevier
Cyanine dyes, one of the most important classes of organic fluorophores, have recently
attracted more and more attention for their applications in fluorescence imaging, tumor …

Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients

R Pal, TM Lwin, M Krishnamoorthy… - Nature Biomedical …, 2023‏ - nature.com
The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging.
However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the …

The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications

X Zhao, F Zhang, Z Lei - Chemical Science, 2022‏ - pubs.rsc.org
Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II)
fluorophores, recently received increasing attention due to their high molar extinction …

Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging

DH Li, RS Gamage, AG Oliver, NL Patel… - Angewandte …, 2023‏ - Wiley Online Library
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …

Bright Chromenylium Polymethine Dyes Enable Fast, Four-Color In Vivo Imaging with Shortwave Infrared Detection

ED Cosco, BA Arús, AL Spearman… - Journal of the …, 2021‏ - ACS Publications
Optical imaging within the shortwave infrared (SWIR, 1000–2000 nm) region of the
electromagnetic spectrum has enabled high-resolution and high-contrast imaging in mice …

THQ–Xanthene: An Emerging Strategy to Create Next‐Generation NIR‐I/II Fluorophores

Z Mao, H Rha, J Kim, X You, F Zhang, W Tao… - Advanced …, 2023‏ - Wiley Online Library
Near‐infrared fluorescence imaging is vital for exploring the biological world. The short
emissions (< 650 nm) and small Stokes shifts (< 30 nm) of current xanthene dyes obstruct …