The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Inflammasomes are essential complexes of innate immune system, which form the first line
of host defense against pathogens. Mounting evidence accumulates that inflammasome …

A growing number of studies are revealing that cells can send and receive information by
controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we …

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable
manner, as a result of their immediate structural breakdown. Such an unavoidable variant of …

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes
limit component-by-component approaches to understanding human disease. Network …

In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein
concentrations,,,,,,. In mammalian cells, protein levels also vary,, and individual cells differ …

Molecular noise restricts the ability of an individual cell to resolve input signals of different
strengths and gather information about the external environment. Transmitting information …

Apoptosis is an evolutionarily conserved form of programmed cell death critical for
development and tissue homeostasis in animals. The apoptotic control network includes …

Cell death plays an essential role in the development of tissues and organisms, the etiology
of disease, and the responses of cells to therapeutic drugs. Here we review progress made …