Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

INTRODUCTION In human cells, 2 m of DNA are compacted in the nucleus through
assembly with histones and other proteins into chromatin structures, megabase three …

The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

RNA polymerase II–mediated eukaryotic transcription starts with the assembly of the
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …

Among the diverse transcription factors that are necessary to elicit changes in cell fate, both
in embryonic development and in cellular reprogramming, a subset of factors are capable of …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to
ionizing radiation. The repair of DSBs involves both posttranslational modification of …