Inflammation underlies many chronic and degenerative diseases, but it also mitigates
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …

We survive because we adapted to a world of microorganisms. All our epithelial surfaces
participate in kee** up an effective barrier against microbes while not initiating ongoing …

Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell
proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can …

The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair.
A key part of the regenerative response is the transient reprogramming of epithelial cells into …

Macrophages, which exhibit great plasticity, are important components of the inflamed tissue
and constitute an essential element of regenerative responses. Epithelial Wnt signalling is …

Helicobacter pylori is a pathogen that colonizes the stomach and causes chronic gastritis.
Helicobacter pylori can colonize deep inside gastric glands, triggering increased R‐spondin …

Enhancement of Wnt signaling is fundamental for stem cell function during intestinal
regeneration. Molecular modules control Wnt activity by regulating signal transduction …

The fourth member of the leucine-rich repeat–containing GPCR family (LGR4, frequently
referred to as GPR48) and its cognate ligands, R-spondins (RSPOs) play crucial roles in the …

Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4/GPR48), a member of
the GPCR (G protein-coupled receptors) superfamily, subfamily B, is a common intestinal …

The key signaling networks regulating mammary stem cells are poorly defined. The leucine-
rich repeat containing G protein-coupled receptor (Lgr) family has been implicated in …