Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

The haemoflagellate protozoan Trypanosoma cruzi (T. cruzi) is the causative agent of
Chagas disease (CD), a potentially life-threatening disease. Little by little, remarkable …

Naphthoquinones are compounds present in several families of higher plants. Their
molecular structures confer redox properties, and they are involved in multiple biological …

The family Trypanosomatidae, flagellated parasitic protozoa, is responsible for important
infectious diseases in humans: slee** sickness, Chagas diseases and leishmaniasis …

The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania
spp. are the causative agents of African trypanosomiasis, Chagas disease, and …

Autophagy is the degradative process by which eukaryotic cells digest their own
components using acid hydrolases within the lysosome. Originally thought to function almost …

Electron microscopy has proven to be a reliable and essential tool to determine
morphological alterations and target organelles in the investigation of new drugs for Chagas …

Eukaryotic cells can degrade their own components, cytosolic proteins and organelles,
using dedicated hydrolases contained within the acidic interior of their lysosomes. This …

Abstract “Molecular modeling” can also be alternatively expressed as “CADD”(Computer-
aided drug design) or “CAMD”(computer assisted molecular design), etc.(Yu and Mackerell …

[1, 2, 3]-Triazole derivatives of nor-β-lapachone were synthesized and assayed against the
infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of …