Versatile phospholipid assemblies for functional synthetic cells and artificial tissues
The bottom‐up construction of a synthetic cell from nonliving building blocks capable of
mimicking cellular properties and behaviors helps to understand the particular biophysical …
mimicking cellular properties and behaviors helps to understand the particular biophysical …
Growth, replication and division enable evolution of coacervate protocells
Living and proliferating cells undergo repeated cycles of growth, replication and division, all
orchestrated by complex molecular networks. How a minimal cell cycle emerged and helped …
orchestrated by complex molecular networks. How a minimal cell cycle emerged and helped …
Peptide‐based coacervate‐core vesicles with semipermeable membranes
Coacervates droplets have long been considered as potential protocells to mimic living
cells. However, these droplets lack a membrane and are prone to coalescence, limiting their …
cells. However, these droplets lack a membrane and are prone to coalescence, limiting their …
Transcription and translation in cytomimetic protocells perform most efficiently at distinct macromolecular crowding conditions
MA Vibhute, MH Schaap, RJM Maas… - ACS Synthetic …, 2020 - ACS Publications
The formation of cytomimetic protocells that capture the physicochemical aspects of living
cells is an important goal in bottom-up synthetic biology. Here, we recreated the crowded …
cells is an important goal in bottom-up synthetic biology. Here, we recreated the crowded …
Structure‐Property Relationships Governing Membrane‐Penetrating Behaviour of Complex Coacervates
Complex coacervates are phase‐separated liquid droplets composed of oppositely charged
multivalent molecules. The unique material properties of the complex coacervate interior …
multivalent molecules. The unique material properties of the complex coacervate interior …
Effect of osmotic pressure on pore formation in lipid bilayers by the antimicrobial peptide magainin 2
Osmotic pressure (Π) induces membrane tension in cells and lipid vesicles, which may affect
the activity of antimicrobial peptides (AMPs) by an unknown mechanism. We recently …
the activity of antimicrobial peptides (AMPs) by an unknown mechanism. We recently …
Structural stability of liposome-stabilized oil-in-water pickering emulsions and their fate during in vitro digestion
W Liu, J Liu, LJ Salt, MJ Ridout, J Han, PJ Wilde - Food & function, 2019 - pubs.rsc.org
Most current research on food-relevant Pickering emulsions has been conducted using
inorganic or food-compatible organic particles as emulsifiers. A key challenge is maintaining …
inorganic or food-compatible organic particles as emulsifiers. A key challenge is maintaining …
Simulations of morphology control of self‐assembled amphiphilic surfactants
One of the grand challenges of amphiphilic self‐assembly is the design of ordered structures
whose morphology or shape can be explicitly and dynamically controlled by adjusting the …
whose morphology or shape can be explicitly and dynamically controlled by adjusting the …
High macromolecular crowding in liposomes from microfluidics
LPB Guerzoni, AVC de Goes, M Kalacheva… - Advanced …, 2022 - Wiley Online Library
The intracellular environment is crowded with macromolecules that influence biochemical
equilibria and biomacromolecule diffusion. The incorporation of such crowding in synthetic …
equilibria and biomacromolecule diffusion. The incorporation of such crowding in synthetic …
To close or to collapse: the role of charges on membrane stability upon pore formation
Resealing of membrane pores is crucial for cell survival. Membrane surface charge and
medium composition are studied as defining regulators of membrane stability. Pores are …
medium composition are studied as defining regulators of membrane stability. Pores are …