Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a
larger fraction of pyruvate into lactate, even under normoxic conditions; this phenomenon of …

Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator
of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate …

Although cancer is a diverse set of diseases, cancer cells share a number of adaptive
hallmarks. Dysregulated pH is emerging as a hallmark of cancer because cancers show …

Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-
CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been …

Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is
attributed to its regulation of the cell cycle. Here, we show how Wnt/β‐catenin signaling …

Alterations in tumour metabolism and acid/base regulation result in the formation of a hostile
environment, which fosters tumour growth and metastasis. Acid/base homoeostasis in …

Tumors contain oxygenated and hypoxic regions, so the tumor cell population is
heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production …

Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …