This Perspective presents a review of our work and that of others in the highly controversial
topic of the coupling of protein dynamics to reaction in enzymes. We have been involved in …

Biologically active derivatives of vitamin B12 are organometallic cobalt-corrinoid complexes
crucial for the healthy function of humans, animals and microbes. Their role as cofactors to …

Coupling of fast protein dynamics to enzyme chemistry is controversial and has ignited
considerable debate, especially over the past 15 years in relation to enzyme-catalyzed H …

This Perspective Article highlights recent theoretical developments, and summarizes the
current understanding of the photolytic properties of cobalamins from a computational point …

The biologically active forms of vitamin B 12, methylcobalamin (MeCbl) and
adenosylcobalamin (AdoCbl), are important cofactors in a variety of enzymatic processes. In …

Enzymes undergo a range of internal motions from local, active site fluctuations to large‐
scale, global conformational changes. These motions are often important for enzyme …

Adenosylcobalamin, a coenzyme form of vitamin B 12, is an organometallic compound that
participates in about ten enzymatic reactions. These enzymes catalyze chemically …

Many animals can sense the geomagnetic field, which appears to aid in behaviours such as
migration. The influence of man-made magnetic fields on biology, however, is potentially …

A mechanism of Co–C bond photodissociation in the base-on form of adenosylcobalamin
(AdoCbl) was investigated by time-dependent density functional theory (TD-DFT). The key …

Ligand–receptor molecular recognitionis the basis of biological process. The Saturation
Transfer Difference–NMR (STD–NMR) technique has been recently used to gain qualitative …