The red cell membrane skeleton is a pseudohexagonal meshwork of spectrin, actin, protein
4.1 R, ankyrin, and actin-associated proteins that laminates the inner membrane surface and …

Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

The zebrafish is firmly established as a genetic model for the study of vertebrate blood
development. Here we have characterized the blood-forming system of adult zebrafish. Each …

Iron has a fundamental role in many metabolic processes, including electron transport,
deoxyribonucleotide synthesis, oxygen transport and many essential redox reactions …

The usage of copper (II) oxide nanoparticles (CuO NPs) has significantly expanded across
industries and biomedical fields. However, the potential toxic effects on non-target …

Progressive advances using zebrafish as a model organism have provided hematologists
with an additional genetic system to study blood cell formation and hematological …

Thrombocytes are the nucleated equivalent of platelets in nonmammalian vertebrates such
as the zebrafish, Danio rerio. We have cloned zebrafish CD41 cDNA (αIIb, glycoprotein IIb …

The zebrafish is a powerful model system for investigating embryonic vertebrate
hematopoiesis, allowing for the critical in vivo analysis of cell lineage determination. In this …

Congenital dyserythropoietic anemias (CDAs) are phenotypically and genotypically
heterogeneous diseases,,,. CDA type II (CDAII) is the most frequent CDA. It is characterized …