Understanding mechanisms of antioxidant action in health and disease

B Halliwell - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …

Fundamentals of redox regulation in biology

H Sies, RJ Mailloux, U Jakob - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

Several lines of antioxidant defense against oxidative stress: Antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024 - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis

B Wang, Y Wang, J Zhang, C Hu, J Jiang, Y Li… - Archives of …, 2023 - Springer
Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal
and other related products, which play an important role in the process of cell death …

The pleiotropic functions of reactive oxygen species in cancer

K Wu, AE El Zowalaty, VI Sayin… - Nature Cancer, 2024 - nature.com
Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Targeting ROS in cancer: rationale and strategies

C Glorieux, S Liu, D Trachootham… - Nature Reviews Drug …, 2024 - nature.com
Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

Microenvironment-responsive metal-phenolic nanozyme release platform with antibacterial, ROS scavenging, and osteogenesis for periodontitis

Y Xu, Y Luo, Z Weng, H Xu, W Zhang, Q Li, H Liu… - ACS …, 2023 - ACS Publications
Periodontitis is a chronic inflammatory disease deriving from dental plaque, characterized by
the excessive accumulation of reactive oxygen species (ROS), matrix metalloproteinase …

ROS: Basic concepts, sources, cellular signaling, and its implications in aging pathways

AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia

CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

S Afzal, AS Abdul Manap, A Attiq… - Frontiers in …, 2023 - frontiersin.org
Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …