Towards an understanding of psychedelic-induced neuroplasticity

AE Calder, G Hasler - Neuropsychopharmacology, 2023 - nature.com
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

Psychedelics, mystical experience, and therapeutic efficacy: A systematic review

K Ko, G Knight, JJ Rucker, AJ Cleare - Frontiers in psychiatry, 2022 - frontiersin.org
The mystical experience is a potential psychological mechanism to influence outcome in
psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution …

Single-dose psilocybin treatment for major depressive disorder: a randomized clinical trial

CL Raison, G Sanacora, J Woolley, K Heinzerling… - Jama, 2023 - jamanetwork.com
Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up

N Gukasyan, AK Davis, FS Barrett… - Journal of …, 2022 - journals.sagepub.com
Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis

K Ko, EI Kopra, AJ Cleare, JJ Rucker - Journal of Affective Disorders, 2023 - Elsevier
Background Psychedelic therapy shows promise for Major Depressive Disorder, especially
when treatment-resistant, as well as life-threatening illness distress. The objective of this …

Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants

W Duan, D Cao, S Wang, J Cheng - Chemical Reviews, 2023 - ACS Publications
Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

Psilocybin-assisted therapy for major depressive disorder: An exploratory placebo-controlled, fixed-order trial

J Sloshower, PD Skosnik… - Journal of …, 2023 - journals.sagepub.com
Background: Several early phase studies have demonstrated that psilocybin-assisted
therapy has rapid-acting and persisting antidepressant effects from just one or two doses …

Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies

KAA Andersen, R Carhart‐Harris… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective To conduct a systematic review of modern‐era (post‐millennium) clinical studies
assessing the therapeutic effects of serotonergic psychedelics drugs for mental health …

Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis

Y Yao, D Guo, TS Lu, FL Liu, SH Huang, MQ Diao… - Psychiatry …, 2024 - Elsevier
We aim to systematically review and meta-analyze the effectiveness and safety of
psychedelics [psilocybin, ayahuasca (active component DMT), LSD and MDMA] in treating …

Psychedelic-assisted psychotherapy—a systematic review of associated psychological interventions

M Cavarra, A Falzone, JG Ramaekers… - Frontiers in …, 2022 - frontiersin.org
Modern clinical research on psychedelics is generating interesting outcomes in a wide array
of clinical conditions when psychedelic-assisted psychotherapy is delivered to appropriately …