Early diagnosis of pancreatic cancer: challenges and new developments

S Kaur, MJ Baine, M Jain, AR Sasson… - Biomarkers in …, 2012 - Taylor & Francis
Pancreatic cancer is a lethal malignancy with its incidence almost equivalent to mortality.
The complex pathophysiology, absence of early diagnostic and prognostic markers and …

The peripheral-blood transcriptome: new insights into disease and risk assessment

S Mohr, CC Liew - Trends in molecular medicine, 2007 - cell.com
Future personalized medicine strategies for assessing an individual's health require, ideally,
a noninvasive system that is capable of integrating numerous interactive factors, including …

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

LW Harries, D Hernandez, W Henley, AR Wood… - Aging cell, 2011 - Wiley Online Library
Aging is a major risk factor for chronic disease in the human population, but there are little
human data on gene expression alterations that accompany the process. We examined …

Cell-type specific gene expression profiles of leukocytes in human peripheral blood

C Palmer, M Diehn, AA Alizadeh, PO Brown - BMC genomics, 2006 - Springer
Background Blood is a complex tissue comprising numerous cell types with distinct functions
and corresponding gene expression profiles. We attempted to define the cell type specific …

Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells

ME Burczynski, RL Peterson, NC Twine… - The journal of molecular …, 2006 - Elsevier
Ulcerative colitis (UC) and Crohn's disease (CD) are common inflammatory bowel diseases
producing intestinal inflammation and tissue damage. Although emerging evidence …

PBMCs: a new source of diagnostic and prognostic biomarkers

M Mosallaei, N Ehtesham, S Rahimirad… - … of physiology and …, 2022 - Taylor & Francis
There are various types of molecular biomarkers that are derived from distinct starting
materials. Although many indirect biomarkers are found in blood, their detection remains a …

Assessing the validity of blood‐based gene expression profiles for the classification of schizophrenia and bipolar disorder: A preliminary report

MT Tsuang, N Nossova, T Yager… - American Journal of …, 2005 - Wiley Online Library
Recent advances have facilitated the use of blood‐derived RNA to conduct genomic
analyses of human diseases. This emerging technology represents a rigorous and …

Comparison of different isolation techniques prior gene expression profiling of blood derived cells: impact on physiological responses, on overall expression and the …

S Debey, U Schoenbeck, M Hellmich… - The …, 2004 - nature.com
Owing to its clinical accessibility, peripheral blood is probably the best source for the
assessment of differences or changes in gene expression associated with disease or drug …

[HTML][HTML] Gene expression changes in children with autism

JP Gregg, L Lit, CA Baron, I Hertz-Picciotto, W Walker… - Genomics, 2008 - Elsevier
The objective of this study was to identify gene expression differences in blood differences in
children with autism (AU) and autism spectrum disorder (ASD) compared to general …

Molecular characterization of breast cancer cell lines through multiple omic approaches

SE Smith, P Mellor, AK Ward, S Kendall… - Breast Cancer …, 2017 - Springer
Background Breast cancer cell lines are frequently used as model systems to study the
cellular properties and biology of breast cancer. Our objective was to characterize a large …