Iron metabolism in pathogenic bacteria

C Ratledge, LG Dover - Annual reviews in microbiology, 2000 - annualreviews.org
▪ Abstract The ability of pathogens to obtain iron from transferrins, ferritin, hemoglobin, and
other iron-containing proteins of their host is central to whether they live or die. To combat …

Specific immune-based diagnosis of tuberculosis

P Andersen, ME Munk, JM Pollock, TM Doherty - The Lancet, 2000 - thelancet.com
Current diagnostic tests for tuberculosis based on tuberculin have poor specificity, and both
BCG vaccination and exposure to non-tuberculosis mycobacteria produce a response …

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

ST Cole, R Brosch, J Parkhill, T Garnier, C Churcher… - Nature, 1998 - nature.com
As a result of an error during film output, Table 1 was published with some symbols missing.
The correct version can be found at http://www. sanger. ac. uk and is reproduced again here …

Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

E Campos-Pardos, S Uranga, A Picó, AB Gómez… - Nature …, 2024 - nature.com
Human and animal tuberculosis is caused by the Mycobacterium tuberculosis Complex
(MTBC), which has evolved a genomic decay of cobalamin (vitamin B12) biosynthetic …

Comparative genomics of BCG vaccines by whole-genome DNA microarray

MA Behr, MA Wilson, WP Gill, H Salamon… - Science, 1999 - science.org
Bacille Calmette-Guérin (BCG) vaccines are live attenuated strains of Mycobacterium bovis
administered to prevent tuberculosis. To better understand the differences between M …

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

AS Pym, P Brodin, R Brosch, M Huerre… - Molecular …, 2002 - Wiley Online Library
Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

P Supply, M Marceau, S Mangenot, D Roche… - Nature …, 2013 - nature.com
Global spread and limited genetic variation are hallmarks of M. tuberculosis, the agent of
human tuberculosis. In contrast, Mycobacterium canettii and related tubercle bacilli that also …

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

TP Stinear, T Seemann, PF Harrison… - Genome …, 2008 - genome.cshlp.org
Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of …

Genome plasticity of BCG and impact on vaccine efficacy

R Brosch, SV Gordon, T Garnier, K Eiglmeier… - Proceedings of the …, 2007 - pnas.org
To understand the evolution, attenuation, and variable protective efficacy of bacillus
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been …

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

AS Pym, P Brodin, L Majlessi, R Brosch, C Demangel… - Nature medicine, 2003 - nature.com
The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and
Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early …