Neisseria gonorrhoeae is evolving into a superbug with resistance to previously and
currently recommended antimicrobials for treatment of gonorrhea, which is a major public …

Efflux pump genes and proteins are present in both antibiotic-susceptible and antibiotic-
resistant bacteria. Pumps may be specific for one substrate or may transport a range of …

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease.
And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of …

This paper demonstrates the use of graphs as a mathematical tool for expressing
independencies, and as a formal language for communicating and processing causal …

We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

Multidrug efflux systems display the ability to transport a variety of structurally unrelated
drugs from a cell and consequently are capable of conferring resistance to a diverse range …

Multiresistance in Gram-negative pathogens, particularly Pseudomonas aeruginosa,
Stenotrophomonas maltophilia, Acinetobacter spp. and the Enterobacteriaceae, is a …

Antibiotic resistance of bacterial pathogens is a fast emerging global crisis and an
understanding of the underlying resistance mechanisms is paramount for design and …

Mosaic interspecifically acquired alleles of the multiple transferable resistance (mtr) efflux
pump operon correlate with increased resistance to azithromycin in Neisseria gonorrhoeae …

Minimum inhibitory concentrations (MICs) of most lipophilic agents tend to be much higher
against gram-negative than gram-positive bacteria. Multidrug efflux pumps that traverse both …