In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

Data-independent acquisition (DIA) proteomics is a recently-developed global mass
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …

Abstract Carboxylesterases (CES1 and CES2) and arylacetamide deacetylase (AADAC),
which are expressed primarily in the liver and/or gastrointestinal tract, hydrolyze drugs …

Background Previous expression quantitative trait loci (eQTL) studies have identified
thousands of genetic variants to be associated with gene expression at the mRNA level in …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …

C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative
pathway of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit …

Objective: Based on the 4D label-free phosphoproteomic technique, we examined the
differences in cognitive function and hippocampal phosphorylated protein expression in …

Schizophrenia is a severe psychological disorder. The current diagnosis mainly relies on
clinical symptoms and lacks laboratory evidence, which makes it very difficult to make an …

Sclerotinia stem rot is a common disease found in Brassica rapa that is caused by the
necrotic plant pathogen Sclerotinia sclerotiorum. Melatonin (MT) has known biological …