Oxidative stress is induced by an imbalanced redox states, involving either excessive
generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

Pathophysiology The establishment of a model of parkinsonism through the administration
of MPTP to nonhuman primates has provided important insights into new therapeutic …

The mitochondrial electron transport chain (ETC) enables many metabolic processes, but
why its inhibition suppresses cell proliferation is unclear. It is also not well understood why …

Quinones represent a class of toxicological intermediates which can create a variety of
hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis …

Parkinson's disease (PD) is a complex disorder with many different causes, yet they may
intersect in common pathways, raising the possibility that neuroprotective agents may have …

Parkinson disease (PD) is a multifactorial neurodegenerative disorder, the etiology of which
remains largely unknown. Progressive impairment of voluntary motor control, which …

Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …

▪ Abstract Parkinson's disease (PD) is an age-related neurodegenerative disorder that
affects approximately 1 million persons in the United States. It is characterized by resting …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …