Pseudomonas aeruginosa is a leading cause of nosocomial infections and is responsible
for∼ 10% of all hospital-acquired infections worldwide. It continues to pose a therapeutic …

The host inflammatory response in cystic fibrosis (CF) lung disease has long been
recognized as a central pathological feature and an important therapeutic target. Indeed …

The innate immune system is the first line of defense against pathogens and is characterized
by its fast but nonspecific response. One important mechanism of this system is the …

Cystic fibrosis is a lethal autosomal recessive condition caused by a defect of the
transmembrane conductance regulator gene that has a key role in cell homeostasis. A …

Myeloperoxidase (MPO) is recognised to play important roles both in the immune system
and during the development of numerous human pathologies. MPO is released by activated …

Thiocyanate (SCN) functions in host defense as part of the secreted lactoperoxidase (LPO)
microbicidal pathway. SCN is the preferred substrate for LPO-driven catalytic reduction of …

The NOX/DUOX family of NADPH oxidases are transmembrane proteins generating reactive
oxygen species as their primary enzymatic products. NADPH oxidase (NOX) 1–5 and Dual …

The major pathogen Staphylococcus aureus has to cope with host‐derived oxidative stress
to cause infections in humans. Here, we report that S. aureus tolerates high concentrations …

Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is
caused by mutations in the gene encoding CFTR with the most common phenylalanine …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a …