Physiological and pathological roles of aldose reductase
Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …
Recent developments on the potential biological applications of transition metal complexes of thiosemicarbazone derivatives
This review talks about the synthesis, and coordination chemistry of thiosemicarbazone and
its bonding with transition metals like copper, nickel, zinc, palladium, and ruthenium and …
its bonding with transition metals like copper, nickel, zinc, palladium, and ruthenium and …
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
Abstract Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase …
With the fading of 'one drug-one target'approach, Multi-Target-Directed Ligands (MTDL) has
become a central idea in modern Medicinal Chemistry. The present study aimed to design …
become a central idea in modern Medicinal Chemistry. The present study aimed to design …
N‐substituted phthalazine sulfonamide derivatives as non‐classical aldose reductase inhibitors
Abstract Aldose reductase (AR, AKR1B1; EC 1.1. 1.21) is an aldo‐keto reductase that has
been widely investigated as an enzyme crucially involved in the pathogenesis of several …
been widely investigated as an enzyme crucially involved in the pathogenesis of several …
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus
A Kousaxidis, A Petrou, V Lavrentaki… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
[HTML][HTML] Thiosemicarbazone derivatives of transition metals as multi-target drugs: a review
S Gupta, N Singh, T Khan, S Joshi - Results in Chemistry, 2022 - Elsevier
The mutations of bacteria and viruses along with the resistance of various targets to the
existing drugs have emerged as great challenges in the medical field. This imposes the …
existing drugs have emerged as great challenges in the medical field. This imposes the …
Design, synthesis, biological activity, molecular docking and computational studies on novel 1, 4-disubstituted-1, 2, 3-Triazole-Thiosemicarbazone hybrid molecules
A library of some novel 1, 4-disubstituted-1, 2, 3-triazole-thiosemicarbazone hybrid
molecules were designed and synthesized from (4-Prop-2-ynyloxy-benzylidene) …
molecules were designed and synthesized from (4-Prop-2-ynyloxy-benzylidene) …
Influence of complexation of thiosemicarbazone derivatives with Cu (II) ions on their antitumor activity against melanoma cells
M Pitucha, A Korga-Plewko, A Czylkowska… - International journal of …, 2021 - mdpi.com
A series of thiosemicarbazone derivatives was prepared and their anti-tumor activity in vitro
was tested. The X-ray investigation performed for compounds T2, T3 and T5 confirmed the …
was tested. The X-ray investigation performed for compounds T2, T3 and T5 confirmed the …
Synthesis and characterization of new thiosemicarbazones, as potent urease inhibitors: In vitro and in silico studies
A new series of N-substituted thiosemicarbazones (3a-u) bearing 2-naphthyl and
dihydrobenzofuranyl scaffolds were synthesized in good to excellent yields (78–95%). The …
dihydrobenzofuranyl scaffolds were synthesized in good to excellent yields (78–95%). The …