Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

The cilium is a complex organelle, the assembly of which requires the coordination of motor-
driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium …

The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

The cilium is a large macromolecular machine that is vital for motility, signaling, and sensing
in most eukaryotic cells. Its conserved core structure, the axoneme, contains nine …

Intraflagellar transport (IFT) of ciliary precursors such as tubulin from the cytoplasm to the
ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most …

Cilia and flagella have attracted tremendous attention in recent years as research
demonstrated crucial roles for these organelles in coordinating a number of physiologically …

Intraflagellar transport (IFT) relies on the IFT complex and is required for ciliogenesis. The
IFT‐B complex consists of 9–10 stably associated core subunits and six “peripheral” …

Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other
mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single …

In recent decades, cilia have moved from relative obscurity to a position of importance for
understanding multiple complex human diseases. Now termed the ciliopathies, these …

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein–
based intracellular transport. Microtubule networks are highly diverse across different cell …