The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …

Metastasis is the main cause of death for patients with breast cancer. Many studies have
characterized the genomic landscape of breast cancer during its early stages. However …

Abstract KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among
the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how …

Estrogen is a steroid hormone that has critical roles in reproductive development, bone
homeostasis, cardiovascular remodeling and brain functions. However, estrogen also …

Phenotypic plasticity associated with the hybrid epithelial–mesenchymal transition (EMT) is
crucial to metastatic seeding and outgrowth. However, the mechanisms governing the hybrid …

Tumors from individuals with cancer are frequently genetically profiled for information about
the driving forces behind the disease. We present the CancerMine resource, a text-mined …

The KMT2 (lysine methyltransferase) family of histone modifying proteins play essential
roles in regulating developmental pathways, and mutations in the genes encoding these …

Background Little is known about mechanisms of resistance to poly (adenosine diphosphate-
ribose) polymerase inhibitors (PARPi) and platinum chemotherapy in patients with …

Abstract Background Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus
endocrine therapy (ET) is an effective treatment for patients with hormone receptor …