Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

The digitization of health records and growing availability of tumour DNA sequencing
provide an opportunity to study the determinants of cancer outcomes with unprecedented …

Cancer and its metastases arise from mutations of genes, drivers that promote a tumor's
growth. Analyses of driver events provide insights into cancer cell history and may lead to a …

Brain metastases frequently develop in patients with non-small cell lung cancer (NSCLC)
and are a common cause of cancer-related deaths, yet our understanding of the underlying …

Genomic profiling of central nervous system (CNS) metastases has the potential to guide
treatments. In the present study, we included 584 patients with non-small-cell lung cancer …

Brain metastasis is a major cause of poor prognosis and death in lung adenocarcinoma
(LUAD); however, the understanding of therapeutic strategies and mechanisms for brain …

The increasing prevalence and poor prognosis of central nervous system (CNS) metastases
pose a significant challenge in oncology, necessitating improved therapeutic strategies …

Background Brain metastasis (BM) is a rare but severe complication of head and neck
squamous cell carcinoma (HNSCC), with limited knowledge of molecular characteristics and …

Brain metastasis from lung cancer is a prevalent mode of treatment failure associated with a
poor prognosis. The incidence of brain metastasis has recently shown a dramatic increase …

Tumor-associated macrophages (TAMs) are key regulators in tumor progression, but the
precise role of bone marrow-derived monocytes (Mons) as TAM precursors and their …