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[HTML][HTML] Metazoan micrornas
DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
Micro RNA s in metabolism
S Vienberg, J Geiger, S Madsen… - Acta …, 2017 - Wiley Online Library
Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …
metabolic homoeostasis. Major tissues in intermediary metabolism important during …
MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics
JA Deiuliis - International journal of obesity, 2016 - nature.com
The prevalence of overweight and obesity in developed and develo** countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …
Comparative regenerative mechanisms across different mammalian tissues
Stimulating regeneration of complex tissues and organs after injury to effect complete
structural and functional repair, is an attractive therapeutic option that would revolutionize …
structural and functional repair, is an attractive therapeutic option that would revolutionize …
Diabetes mellitus—advances and challenges in human β-cell proliferation
P Wang, NM Fiaschi-Taesch, RC Vasavada… - Nature Reviews …, 2015 - nature.com
The treatment of diabetes mellitus represents one of the greatest medical challenges of our
era. Diabetes results from a deficiency or functional impairment of insulin-producing β cells …
era. Diabetes results from a deficiency or functional impairment of insulin-producing β cells …
[HTML][HTML] MicroRNAs as stress regulators in pancreatic beta cells and diabetes
MP LaPierre, M Stoffel - Molecular metabolism, 2017 - Elsevier
Background MicroRNAs have emerged as important regulatory non-coding RNAs that tune
cellular responses to physiological perturbations and disease conditions. An increasing …
cellular responses to physiological perturbations and disease conditions. An increasing …
The profiling and role of miRNAs in diabetes mellitus
M Kim, X Zhang - Journal of diabetes and clinical research, 2019 - pmc.ncbi.nlm.nih.gov
Diabetes mellitus (DM), a complex metabolic disease, has become a global threat to human
health worldwide. Over the past decades, an enormous amount of effort has been devoted to …
health worldwide. Over the past decades, an enormous amount of effort has been devoted to …
MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion
Aims MicroRNAs are a class of negative regulators of gene expression, which have been
shown to be involved in the development of endocrine pancreas and in the regulation of …
shown to be involved in the development of endocrine pancreas and in the regulation of …
MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications
R Regazzi - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Diabetes mellitus is a very common metabolic disorder affecting more than 400
million people worldwide. Currently available treatments permit to manage the disease but …
million people worldwide. Currently available treatments permit to manage the disease but …
β-cell microRNAs: small but powerful
SR Filios, A Shalev - Diabetes, 2015 - diabetesjournals.org
Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of
key processes in cell biology, including development, differentiation, and survival. Currently …
key processes in cell biology, including development, differentiation, and survival. Currently …