[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Micro RNA s in metabolism

S Vienberg, J Geiger, S Madsen… - Acta …, 2017 - Wiley Online Library
Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …

MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics

JA Deiuliis - International journal of obesity, 2016 - nature.com
The prevalence of overweight and obesity in developed and develo** countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …

Comparative regenerative mechanisms across different mammalian tissues

SE Iismaa, X Kaidonis, AM Nicks, N Bogush… - NPJ Regenerative …, 2018 - nature.com
Stimulating regeneration of complex tissues and organs after injury to effect complete
structural and functional repair, is an attractive therapeutic option that would revolutionize …

Diabetes mellitus—advances and challenges in human β-cell proliferation

P Wang, NM Fiaschi-Taesch, RC Vasavada… - Nature Reviews …, 2015 - nature.com
The treatment of diabetes mellitus represents one of the greatest medical challenges of our
era. Diabetes results from a deficiency or functional impairment of insulin-producing β cells …

[HTML][HTML] MicroRNAs as stress regulators in pancreatic beta cells and diabetes

MP LaPierre, M Stoffel - Molecular metabolism, 2017 - Elsevier
Background MicroRNAs have emerged as important regulatory non-coding RNAs that tune
cellular responses to physiological perturbations and disease conditions. An increasing …

The profiling and role of miRNAs in diabetes mellitus

M Kim, X Zhang - Journal of diabetes and clinical research, 2019 - pmc.ncbi.nlm.nih.gov
Diabetes mellitus (DM), a complex metabolic disease, has become a global threat to human
health worldwide. Over the past decades, an enormous amount of effort has been devoted to …

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

G Sebastiani, A Po, E Miele, G Ventriglia, E Ceccarelli… - Acta Diabetologica, 2015 - Springer
Aims MicroRNAs are a class of negative regulators of gene expression, which have been
shown to be involved in the development of endocrine pancreas and in the regulation of …

MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications

R Regazzi - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Diabetes mellitus is a very common metabolic disorder affecting more than 400
million people worldwide. Currently available treatments permit to manage the disease but …

β-cell microRNAs: small but powerful

SR Filios, A Shalev - Diabetes, 2015 - diabetesjournals.org
Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of
key processes in cell biology, including development, differentiation, and survival. Currently …