Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …

During interphase, filamentous actin, microtubules, and intermediate filaments regulate cell
shape, motility, transport, and interactions with the environment. These activities rely on …

A-type lamins are the main structural components of the nucleus, which are mainly localized
at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins …

The nuclear envelope (NE) is continuous with the endoplasmic reticulum (ER), yet the NE
carries out many functions distinct from those of bulk ER. This functional specialization …

Many human diseases are caused by mutations in nuclear envelope (NE) proteins. How
protein homeostasis and disease etiology are interconnected at the NE is poorly …

The nuclear envelope (NE) is a subdomain of the ER with prominent roles in nuclear
organization, which are largely mediated by its distinctive protein composition. We …

Laminopathies are a diverse group of rare diseases with various pathologies in different
tissues, which are linked to mutations in the LMNA gene. Historically, the structural disease …

The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to
the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells …

Emerin and lamin B receptor (LBR) are abundant transmembrane proteins of the nuclear
envelope that are concentrated at the inner nuclear membrane (INM). Although both …

The nucleus provides a physical and selective chemical boundary to segregate the genome
from the cytoplasm. The contents of the nucleus are surrounded by the nuclear envelope …