TH2 cell development and function
JA Walker, ANJ McKenzie - Nature Reviews Immunology, 2018 - nature.com
Abstract T helper 2 (TH 2) cells orchestrate protective type 2 immune responses, such as
those that target helminths and facilitate tissue repair, but also contribute to chronic …
those that target helminths and facilitate tissue repair, but also contribute to chronic …
Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: the one airway concept revisited
Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co‐exist. The one airway
model proposes that disease mechanisms occurring in the upper airway may mirror lower …
model proposes that disease mechanisms occurring in the upper airway may mirror lower …
A cellular census of human lungs identifies novel cell states in health and in asthma
Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly …
which depends on mucosal immunity for protection against infectious agents. Tightly …
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders
E Wambre, V Bajzik, JH DeLong, K O'Brien… - Science translational …, 2017 - science.org
Allergen-specific type 2 helper T (TH2) cells play a central role in initiating and orchestrating
the allergic and asthmatic inflammatory response pathways. One major factor limiting the …
the allergic and asthmatic inflammatory response pathways. One major factor limiting the …
Endotypes of allergic diseases and asthma: an important step in building blocks for the future of precision medicine
abstract Discoveries from basic science research in the last decade have brought significant
progress in knowledge of pathophysiologic processes of allergic diseases, with a …
progress in knowledge of pathophysiologic processes of allergic diseases, with a …
T helper 2 cells in asthma
Allergic asthma is among the most common immune-mediated diseases across the world,
and type 2 immune responses are thought to be central to pathogenesis. The importance of …
and type 2 immune responses are thought to be central to pathogenesis. The importance of …
Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps
JA Poposki, AI Klingler, BK Tan… - Immunity …, 2017 - Wiley Online Library
Background Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by
type 2 inflammation with high levels of Th2 cytokines. Although T helper cytokines are …
type 2 inflammation with high levels of Th2 cytokines. Although T helper cytokines are …
Emerging endotypes of chronic rhinosinusitis and its application to precision medicine
DW Kim, SH Cho - Allergy, asthma & immunology research, 2017 - synapse.koreamed.org
Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with various
underlying pathophysiologic mechanisms which translate to endotypes, in contrast to clinical …
underlying pathophysiologic mechanisms which translate to endotypes, in contrast to clinical …
Pathogenic CD4+ T cells in patients with asthma
Asthma encompasses a variety of clinical phenotypes that involve distinct T cell–driven
inflammatory processes. Improved understanding of human T-cell biology and the influence …
inflammatory processes. Improved understanding of human T-cell biology and the influence …
Interleukin-33: its emerging role in allergic diseases
W Ding, GL Zou, W Zhang, XN Lai, HW Chen, LX **ong - Molecules, 2018 - mdpi.com
Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS),
atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the …
atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the …