A molecular view of kinetochore assembly and function
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
The molecular basis for centromere identity and function
The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …
meiosis. Although the functional importance of the centromere has been appreciated for …
Molecular complexes at euchromatin, heterochromatin and centromeric chromatin
O Morrison, J Thakur - International Journal of Molecular Sciences, 2021 - mdpi.com
Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …
plays an important role in both packaging DNA and regulating DNA metabolic pathways …
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
Chromosome missegregation into a micronucleus can cause complex and localized
genomic rearrangements, known as chromothripsis, but the underlying mechanisms remain …
genomic rearrangements, known as chromothripsis, but the underlying mechanisms remain …
CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores
K Klare, JR Weir, F Basilico, T Zimniak… - Journal of Cell …, 2015 - rupress.org
Kinetochores are multisubunit complexes that assemble on centromeres to bind spindle
microtubules and promote faithful chromosome segregation during cell division. A 16 …
microtubules and promote faithful chromosome segregation during cell division. A 16 …
The CENP-LN complex forms a critical node in an integrated meshwork of interactions at the centromere-kinetochore interface
During mitosis, the macromolecular kinetochore complex assembles on the centromere to
orchestrate chromosome segregation. The properties and architecture of the 16-subunit …
orchestrate chromosome segregation. The properties and architecture of the 16-subunit …
A variety of changes, including CRISPR/Cas9‐mediated deletions, in CENH3 lead to haploid induction on outcrossing
Creating true‐breeding lines is a critical step in plant breeding. Novel, completely
homozygous true‐breeding lines can be generated by doubled haploid technology in single …
homozygous true‐breeding lines can be generated by doubled haploid technology in single …
The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle
Eukaryotic chromosome segregation relies upon specific connections from DNA to the
microtubule-based spindle that forms at cell division. The chromosomal locus that directs …
microtubule-based spindle that forms at cell division. The chromosomal locus that directs …
Centromere and pericentromere transcription: roles and regulation… in sickness and in health
The chromosomal loci known as centromeres (CEN) mediate the equal distribution of the
duplicated genome between both daughter cells. Specifically, centromeres recruit a protein …
duplicated genome between both daughter cells. Specifically, centromeres recruit a protein …
Decoding the centromeric nucleosome through CENP-N
Centromere protein (CENP) A, a histone H3 variant, is a key epigenetic determinant of
chromosome domains known as centromeres. Centromeres nucleate kinetochores, multi …
chromosome domains known as centromeres. Centromeres nucleate kinetochores, multi …