Most proteins in cells are composed of multiple folding units (or domains) to perform
complex functions in a cooperative manner. Relative to the rapid progress in single-domain …

DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of
Structure Prediction (CASP14) conference. We explored network architectures that …

This is the 4th edition of a book that was initiated with the annotation of the function of all the
genes in the most commonly studied baculovirus, AcMNPV. It has been almost six years …

Predicting the structure of interacting protein chains is a fundamental step towards
understanding protein function. Unfortunately, no computational method can produce …

Abstract The MPI Bioinformatics Toolkit (https://toolkit. tuebingen. mpg. de) provides
interactive access to a wide range of the best‐performing bioinformatics tools and …

Bacterial anti-phage systems are frequently clustered in microbial genomes, forming
defense islands. This property enabled the recent discovery of multiple defense systems …

The ancient, ongoing coevolutionary battle between bacteria and their viruses,
bacteriophages, has given rise to sophisticated immune systems including restriction …

There is a worldwide concern about the new coronavirus 2019‐nCoV as a global public
health threat. In this article, we provide a preliminary evolutionary and molecular …

Eukaryotic genomes contain domesticated genes from integrating viruses and mobile
genetic elements. Among these are homologs of the capsid protein (known as Gag) of long …

Millions of new viral sequences have been identified from metagenomes, but the quality and
completeness of these sequences vary considerably. Here we present CheckV, an …