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[HTML][HTML] Heparan sulfate proteoglycans and viral attachment: true receptors or adaptation bias?
Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged
heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular …
heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular …
COVID-19 antibody therapeutics tracker: a global online database of antibody therapeutics for the prevention and treatment of COVID-19
Facing the COVID-19 global healthcare crisis, scientists worldwide are collaborating to
develop prophylactic and therapeutic interventions against the disease. Antibody …
develop prophylactic and therapeutic interventions against the disease. Antibody …
Discovery of several thousand highly diverse circular DNA viruses
MJ Tisza, DV Pastrana, NL Welch, B Stewart, A Peretti… - elife, 2020 - elifesciences.org
Although millions of distinct virus species likely exist, only approximately 9000 are
catalogued in GenBank's RefSeq database. We selectively enriched for the genomes of …
catalogued in GenBank's RefSeq database. We selectively enriched for the genomes of …
Prophylactic antiviral activity of sulfated glycomimetic oligomers and polymers
L Soria-Martinez, S Bauer, M Giesler… - Journal of the …, 2020 - ACS Publications
In this work, we investigate the potential of highly sulfated synthetic glycomimetics to act as
inhibitors of viral binding/infection. Our results indicate that both long-chain glycopolymers …
inhibitors of viral binding/infection. Our results indicate that both long-chain glycopolymers …
JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor
BA O'Hara, J Morris-Love, GV Gee, SA Haley… - PLoS …, 2020 - journals.plos.org
The human polyomavirus, JCPyV, is the causative agent of progressive multifocal
leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial …
leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial …
JC polyomavirus uses extracellular vesicles to infect target cells
J Morris-Love, GV Gee, BA O'Hara, B Assetta… - MBio, 2019 - journals.asm.org
The endemic human JC polyomavirus (JCPyV) causes progressive multifocal
leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in …
leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in …
Progressive multifocal leukoencephalopathy: pathogenesis, diagnostic tools, and potential biomarkers of response to therapy
F Schweitzer, S Laurent, I Cortese, GR Fink, S Silling… - Neurology, 2023 - neurology.org
JC polyomavirus (JCV) establishes an asymptomatic latent and/or persistent infection in
most of the adult population. However, in immunocompromised individuals, JCV can cause …
most of the adult population. However, in immunocompromised individuals, JCV can cause …
[HTML][HTML] Fifty years of JC polyomavirus: a brief overview and remaining questions
AL Atkinson, WJ Atwood - Viruses, 2020 - mdpi.com
In the fifty years since the discovery of JC polyomavirus (JCPyV), the body of research
representing our collective knowledge on this virus has grown substantially. As the …
representing our collective knowledge on this virus has grown substantially. As the …
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling
R-spondins (RSPOs) amplify WNT signaling during development and regenerative
responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin …
responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin …
Characterization of BK polyomaviruses from kidney transplant recipients suggests a role for APOBEC3 in driving in-host virus evolution
A Peretti, EM Geoghegan, DV Pastrana, S Smola… - Cell host & …, 2018 - cell.com
BK polyomavirus (BKV) frequently causes nephropathy (BKVN) in kidney transplant
recipients (KTRs). BKV has also been implicated in the etiology of bladder and kidney …
recipients (KTRs). BKV has also been implicated in the etiology of bladder and kidney …