Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
infections that produce a wide spectrum of clinical disease severity in humans. The novel …
Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
[HTML][HTML] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …
manifestations have largely been studied in circulation. Here, we examined the relationship …
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …
The mechanism behind influenza virus cytokine storm
Y Gu, X Zuo, S Zhang, Z Ouyang, S Jiang, F Wang… - Viruses, 2021 - mdpi.com
Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-
cell communication and viral clearance in the immune system, but excessive cytokines can …
cell communication and viral clearance in the immune system, but excessive cytokines can …
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
[HTML][HTML] Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response
SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to
respiratory distress and death. A major unresolved question is whether prior immunity to …
respiratory distress and death. A major unresolved question is whether prior immunity to …
Exuberant fibroblast activity compromises lung function via ADAMTS4
Severe respiratory infections can result in acute respiratory distress syndrome (ARDS).
There are no effective pharmacological therapies that have been shown to improve …
There are no effective pharmacological therapies that have been shown to improve …
Human CD8+ T cell cross-reactivity across influenza A, B and C viruses
Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
New fronts emerge in the influenza cytokine storm
XJ Guo, PG Thomas - Seminars in immunopathology, 2017 - Springer
Influenza virus is a significant pathogen in humans and animals with the ability to cause
extensive morbidity and mortality. Exuberant immune responses induced following infection …
extensive morbidity and mortality. Exuberant immune responses induced following infection …