Oxidative DNA damage: mechanisms, mutation, and disease
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a
propensity for increased levels following toxic insult. Although more than 20 base lesions …
propensity for increased levels following toxic insult. Although more than 20 base lesions …
Oxidative DNA damage and disease: induction, repair and significance
The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …
function in inter-and intracellular signalling, and detrimental, modifying cellular …
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
F Toledo, GM Wahl - Nature Reviews Cancer, 2006 - nature.com
Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …
Role of oxidative stress and DNA damage in human carcinogenesis
TB Kryston, AB Georgiev, P Pissis… - … Molecular Mechanisms of …, 2011 - Elsevier
Cells in tissues and organs are continuously subjected to oxidative stress and free radicals
on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin …
on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin …
Glutathione levels in human tumors
This review summarizes clinical studies in which glutathione was measured in tumor tissue
from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung …
from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung …
Redox signaling in the gastrointestinal tract
S Pérez, R Taléns-Visconti, S Rius-Pérez… - Free Radical Biology …, 2017 - Elsevier
Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies
P Karihtala, Y Soini - Apmis, 2007 - Wiley Online Library
Reactive oxygen species (ROS) are formed in mammalian cells as a consequence of
aerobic respiration. Despite multiple conserved redox modulating systems, a given …
aerobic respiration. Despite multiple conserved redox modulating systems, a given …
Cervical microbiota associated with higher grade cervical intraepithelial neoplasia in women infected with high-risk human papillomaviruses
It is increasingly recognized that microbes that reside in and on human body sites play major
roles in modifying the pathogenesis of several diseases, including cancer. However, specific …
roles in modifying the pathogenesis of several diseases, including cancer. However, specific …
Increased formation of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes
A Matsui, T Ikeda, K Enomoto, K Hosoda, H Nakashima… - Cancer letters, 2000 - Elsevier
Reactive oxygen species (ROS) induced damage to DNA plays a major role in
carcinogenesis. In order to estimate the level of oxidative damage and its role in breast …
carcinogenesis. In order to estimate the level of oxidative damage and its role in breast …
[HTML][HTML] Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study
IA Hakim, RB Harris, S Brown, HHS Chow… - The Journal of …, 2003 - Elsevier
Tea drinking has been associated with decreased occurrence of cancer and heart disease.
One potential mechanism for these findings is the strong antioxidant effect of tea …
One potential mechanism for these findings is the strong antioxidant effect of tea …