Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …

The endothelial barrier strictly maintains vascular and tissue homeostasis, and therefore
modulates many physiological processes such as angiogenesis, immune responses, and …

Intercellular junctions are crucial for mechanotransduction, but whether tight junctions
contribute to the regulation of cell–cell tension and adherens junctions is unknown. Here, we …

How vascular endothelial growth factor (VEGF) induces vascular permeability, its first
described function, remains poorly understood. Here, we provide evidence of a novel …

Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have
been associated with defects in the organization of endothelial cell junctions. Understanding …

Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts
vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and …

Endothelial hyperpermeability is a significant problem in vascular inflammation associated
with trauma, ischaemia–reperfusion injury, sepsis, adult respiratory distress syndrome …

Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …

Vascular endothelial growth factor (VEGF) and Angiopoietin 1 (Ang1) are both potent
proangiogenic factors, but, whereas VEGF causes vascular permeability, Ang1 stabilizes …

Endothelial cell–cell junctions regulate vascular permeability, vasculogenesis, and
angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from …