MicroRNAs: roles in cardiovascular development and disease

S Kalayinia, F Arjmand, M Maleki, M Malakootian… - Cardiovascular …, 2021‏ - Elsevier
Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral
artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to …

Zebrafish as a model to study cardiac development and human cardiac disease

J Bakkers - Cardiovascular research, 2011‏ - academic.oup.com
Over the last decade, the zebrafish has entered the field of cardiovascular research as a
new model organism. This is largely due to a number of highly successful small-and large …

Genetic compensation induced by deleterious mutations but not gene knockdowns

A Rossi, Z Kontarakis, C Gerri, H Nolte, S Hölper… - Nature, 2015‏ - nature.com
Cells sense their environment and adapt to it by fine-tuning their transcriptome. Wired into
this network of gene expression control are mechanisms to compensate for gene dosage …

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

H Honkoop, DEM de Bakker, A Aharonov, F Kruse… - Elife, 2019‏ - elifesciences.org
While the heart regenerates poorly in mammals, efficient heart regeneration occurs in
zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes …

A molecular mechanism for Wnt ligand-specific signaling

M Eubelen, N Bostaille, P Cabochette, A Gauquier… - Science, 2018‏ - science.org
INTRODUCTION Wnt signaling is an ancient signaling pathway that has accompanied the
emergence of metazoans and is key to many developmental, physiological, and disease …

Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools

TY Lin, QN Mai, H Zhang, E Wilson, HC Chien… - Nature chemical …, 2024‏ - nature.com
Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and
stimulate the generation of second messengers such as cyclic adenosine monophosphate …

[HTML][HTML] A brain-specific angiogenic mechanism enabled by tip cell specialization

G Schevenels, P Cabochette, M America… - Nature, 2024‏ - nature.com
Vertebrate organs require locally adapted blood vessels,. The gain of such organotypic
vessel specializations is often deemed to be molecularly unrelated to the process of organ …

Haematopoietic stem cells derive directly from aortic endothelium during development

JY Bertrand, NC Chi, B Santoso, S Teng, DYR Stainier… - Nature, 2010‏ - nature.com
A major goal of regenerative medicine is to instruct formation of multipotent, tissue-specific
stem cells from induced pluripotent stem cells (iPSCs) for cell replacement therapies …

[HTML][HTML] Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche

OJ Tamplin, EM Durand, LA Carr, SJ Childs… - Cell, 2015‏ - cell.com
Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire
blood system. We generated a highly specific transgenic reporter of HSPCs in zebrafish …

The formation and function of the cardiac conduction system

JH van Weerd, VM Christoffels - Development, 2016‏ - journals.biologists.com
The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …