The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting
CC Chu, CH Hsing, JP Shieh, CC Chien, CM Ho… - European journal of …, 2014 - Elsevier
Glucocorticoids, used primarily as anti-allergic and anti-inflammatory drugs, are also
effective, alone or combined with other antiemetics, for preventing nausea and vomiting …
effective, alone or combined with other antiemetics, for preventing nausea and vomiting …
Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index
H Schäcke, H Rehwinkel, K Asadullah… - Experimental …, 2006 - Wiley Online Library
Glucocorticoids are highly effective in the therapy of inflammatory and autoimmune
disorders. Their beneficial action is restricted because of their adverse effects upon …
disorders. Their beneficial action is restricted because of their adverse effects upon …
Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor
J Ruzzin, AS Wagman, J Jensen - Diabetologia, 2005 - Springer
Aims/hypothesis Treatment with glucocorticoids, especially at high doses, induces insulin
resistance. The aims of the present study were to identify the potential defects in insulin …
resistance. The aims of the present study were to identify the potential defects in insulin …
Effect of stress on viral–bacterial synergy in bovine respiratory disease: novel mechanisms to regulate inflammation
The severity of bovine respiratory infections has been linked to a variety of factors, including
environmental and nutritional changes, transportation, and social reorganization of weaned …
environmental and nutritional changes, transportation, and social reorganization of weaned …
Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells
EL Humphrey, JHH Williams, MWJ Davie, MJ Marshall - Bone, 2006 - Elsevier
Glucocorticoids are effective anti-inflammatory and immunosuppressive agents, but their use
is often associated with debilitating side effects such as glucocorticoid-induced …
is often associated with debilitating side effects such as glucocorticoid-induced …
Micelle-forming dexamethasone prodrug attenuates nephritis in lupus-prone mice without apparent glucocorticoid side effects
Nephritis is one of the major complications of systemic lupus erythematosus. While
glucocorticoids (GCs) are frequently used as the first-line treatment for lupus nephritis (LN) …
glucocorticoids (GCs) are frequently used as the first-line treatment for lupus nephritis (LN) …
Stress significantly increases mortality following a secondary bacterial respiratory infection
A variety of mechanisms contribute to the viral-bacterial synergy which results in fatal
secondary bacterial respiratory infections. Epidemiological investigations have implicated …
secondary bacterial respiratory infections. Epidemiological investigations have implicated …
Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene− benzoxazine Series
M Barker, M Clackers, R Copley… - Journal of medicinal …, 2006 - ACS Publications
The tetrahydronaphthalene− benzoxazine glucocorticoid receptor (GR) partial agonist 4b
was optimized to produce potent full agonists of GR. Aromatic ring substitution of the …
was optimized to produce potent full agonists of GR. Aromatic ring substitution of the …
Immunomodulating and anti-apoptotic action of ursodeoxycholic acid: where are we and where should we go?
S Bellentani - European journal of gastroenterology & hepatology, 2005 - journals.lww.com
Ursodeoxycholic acid (UDCA) is currently used in clinical practice worldwide not only for the
dissolution of cholesterol gallstones, but also, mainly, to treat patients with chronic …
dissolution of cholesterol gallstones, but also, mainly, to treat patients with chronic …
Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene
The glucocorticoid receptor (GR) is widely expressed in various tissues throughout the
human body. At least three different 3′-splice variants of the GR have been reported: GR-α …
human body. At least three different 3′-splice variants of the GR have been reported: GR-α …