The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting

CC Chu, CH Hsing, JP Shieh, CC Chien, CM Ho… - European journal of …, 2014 - Elsevier
Glucocorticoids, used primarily as anti-allergic and anti-inflammatory drugs, are also
effective, alone or combined with other antiemetics, for preventing nausea and vomiting …

Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index

H Schäcke, H Rehwinkel, K Asadullah… - Experimental …, 2006 - Wiley Online Library
Glucocorticoids are highly effective in the therapy of inflammatory and autoimmune
disorders. Their beneficial action is restricted because of their adverse effects upon …

Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor

J Ruzzin, AS Wagman, J Jensen - Diabetologia, 2005 - Springer
Aims/hypothesis Treatment with glucocorticoids, especially at high doses, induces insulin
resistance. The aims of the present study were to identify the potential defects in insulin …

Effect of stress on viral–bacterial synergy in bovine respiratory disease: novel mechanisms to regulate inflammation

PD Hodgson, P Aich, A Manuja… - Comparative and …, 2005 - Wiley Online Library
The severity of bovine respiratory infections has been linked to a variety of factors, including
environmental and nutritional changes, transportation, and social reorganization of weaned …

Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells

EL Humphrey, JHH Williams, MWJ Davie, MJ Marshall - Bone, 2006 - Elsevier
Glucocorticoids are effective anti-inflammatory and immunosuppressive agents, but their use
is often associated with debilitating side effects such as glucocorticoid-induced …

Micelle-forming dexamethasone prodrug attenuates nephritis in lupus-prone mice without apparent glucocorticoid side effects

Z Jia, X Wang, X Wei, G Zhao, KW Foster, F Qiu… - ACS …, 2018 - ACS Publications
Nephritis is one of the major complications of systemic lupus erythematosus. While
glucocorticoids (GCs) are frequently used as the first-line treatment for lupus nephritis (LN) …

Stress significantly increases mortality following a secondary bacterial respiratory infection

PD Hodgson, P Aich, J Stookey, Y Popowych… - Veterinary …, 2012 - Springer
A variety of mechanisms contribute to the viral-bacterial synergy which results in fatal
secondary bacterial respiratory infections. Epidemiological investigations have implicated …

Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene− benzoxazine Series

M Barker, M Clackers, R Copley… - Journal of medicinal …, 2006 - ACS Publications
The tetrahydronaphthalene− benzoxazine glucocorticoid receptor (GR) partial agonist 4b
was optimized to produce potent full agonists of GR. Aromatic ring substitution of the …

Immunomodulating and anti-apoptotic action of ursodeoxycholic acid: where are we and where should we go?

S Bellentani - European journal of gastroenterology & hepatology, 2005 - journals.lww.com
Ursodeoxycholic acid (UDCA) is currently used in clinical practice worldwide not only for the
dissolution of cholesterol gallstones, but also, mainly, to treat patients with chronic …

Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene

H Russcher, VASH Dalm, FH de Jong… - Journal of …, 2007 - jme.bioscientifica.com
The glucocorticoid receptor (GR) is widely expressed in various tissues throughout the
human body. At least three different 3′-splice variants of the GR have been reported: GR-α …